Little Known Facts About ceesdekker.
Little Known Facts About ceesdekker.
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Halfway by way of his career, Cees Dekker reinvented himself. Soon after many years of hardcore physics, he shifted his concentration to ‘nanobiology’ on the transform in the millennium. A time period he coined himself, as a make a difference of point.
You often get entangled in conversations about science and religion. You've got also composed various guides on the subject. Don’t you believe that in some unspecified time in the future We're going to know almost everything and that God’s purpose will likely be over?
[Laughs] ‘It absolutely was definitely a great risk! At the time, I had been perfectly knowledgeable that it could go Improper and that I could come to be significantly less thriving, but I just disregarded that. Curiosity has generally been my strongest driving pressure. And fortuitously it all labored out.’
Given that 2000, Dekker has shifted the most crucial concentrate of his get the job done towards biophysics in which he scientific tests the properties of single biomolecules and cells using the instruments of nanotechnology. This change of area was driven by his fascination for that extraordinary functioning of biological molecular constructions, and from the prolonged-expression standpoint that numerous fascinating discoveries could be predicted With this industry.[five] Present-day lines of study in his biophysics group are inside the regions of:[6]
2012, discovery that nucleoid occlusion underlies the accuracy of bacterial mobile division; and 1st ever review from the dynamics DNA supercoils and the invention of supercoil hopping
Experimental section diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,
‘At first we looked at Organic units which has a physical watch and acted on The premise from the equipment we realized. It took a few years just before we begun Operating a lot more on the large Organic issues. I then started to phone it nanobiology, a expression that didn't exist at some time.
2011, first in vitro measurements of transportation throughout one biomimetic nuclear pore intricate; growth of multiplexed magnetic tweezers for kilo-molecule experiments; and solved the mechanism of homology recognition in DNA homologous recombination
2003, demonstrated the main biosensors built outside of a carbon nanotube; solved the construction and mechanism of DNA maintenance proteins; and discovery of a completely new system for fabricating good-condition nanopores for DNA translocation
Quite cool, but that wasn’t genuinely where by my curiosity lay. I planned to pioneer And that i had the feeling which was now not possible, since the most appealing fundamental insights had previously been uncovered. But my industry had produced a lot of remarkable new resources to cees dekker measure particular person molecules. I made a decision that I desired to implement this to biology, to have a look at it from the Actual physical point of view.’
In 1993 he was appointed as Associate Professor at Delft University of Know-how. In the mid-nineties Dekker and his staff achieved accomplishment with the invention of the electronic Houses of carbon nanotubes, the first single-molecule transistor and also other nanoscience.
‘That concerns the synthetic mobile, as A part of the Dutch BaSyC initiative. Craig Venter seemed top-down in People times and identified about 5 hundred genes which have been minimally necessary for just a functioning cell. We wish to look bottom-up: how can we shift from a handful of molecules to an entire Organic method?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of a single wire bridging two electrodes
Supercoiling-dependent DNA binding: quantitative modeling and applications to bulk and one-molecule experiments